Sear Carroll MD talks about a considerable amount of research that suggests there are non-drug interventions that can significantly reduce heart disease risk even among people with genetic predispositions to heart trouble. Given that heart disease is the leading cause of death in the U.S. and much of the rest of the world that's pretty important.
There's nothing terribly novel here, and while the interventions may not be quite as easy as they sound, they're also less drastic than one might expect. Basically, eating a little better and exercising a little more can help as much as drugs or help drugs work better.
Link: https://youtu.be/hkO44tzkXyQ by